Skip to content

Exploring the mechanisms of action of lunasin in the treatment of breast cancer

Explorando los mecanismos de acción del lunasin en el tratamiento del cáncer de mama

Breast cancer is one of the most common cancers in women. Its pathology comprises tumor cells and nearby stromal cells, accompanied by cytokines and stimulated molecules, resulting in a favorable microenvironment for tumor progression. Lunasin is a seed-derived peptide with multiple bioactivities. However, the chemopreventive effect of lunasin on different characteristics of breast cancer has not been fully explored.

Lunasin: a peptide with potential

This study aims to explore the chemopreventive mechanisms of lunasin through inflammatory mediators and estrogen-related molecules in breast cancer cells.

Study methodology

Cell types

Estrogen-dependent MCF-7 and estrogen-independent MDA-MB-231 breast cancer cells were used.

Effect of β-estradiol

β-estradiol was used to simulate physiological estrogen. Gene expression, mediator secretion, cell vitality, and apoptosis affecting breast malignancy were explored.

Study Results

Effects on MCF-10A cells

Lunasin did not affect the growth of normal MCF-10A cells.

Effects on cancer cells

Lunasin inhibited the growth of breast cancer cells, increased interleukin (IL)-6 gene expression and protein production at 24 hours, and decreased its secretion at 48 hours.

Interleukin (IL)-6 regulation

Lunasin increased IL-6 gene expression and protein production in breast cancer cells at 24 hours and decreased its secretion at 48 hours.

Regulation of aromatase and estrogen receptors

In both breast cancer cells, aromatase gene and estrogen receptor (ER)α gene activity and expression were decreased by lunasin treatment, whereas ERβ gene levels were significantly increased in MDA- cells. MB-231.

Decreased vascular endothelial growth factor (VEGF)

Lunasin decreased VEGF secretion and cell vitality and induced apoptosis in both breast cancer cell lines.

Induction of apoptosis

Lunasin induced apoptosis in both breast cancer cell lines.

Regulation of the leptin receptor (Ob-R)

Lunasin alone decreased leptin receptor (Ob-R) mRNA expression in MCF-7 cells.

Effect of β-estradiol on cell proliferation

β-estradiol increased the proliferation of MCF-7 cells but not the proliferation of other cells; in particular, lunasin still inhibited the growth and cell vitality of MCF-7 cells in the presence of β-estradiol.

Conclusion

The lunasin seed peptide inhibited the growth of breast cancer cells by regulating inflammatory, angiogenic, and estrogen-related molecules, suggesting that lunasin is a promising chemopreventive agent.

Frequently asked questions about lunasin or lunasin

  1. What is lunasin and where is it derived from?

    Lunasin is a peptide with multiple bioactivities that is derived from seeds.

  2. What was the aim of the study?

    The study aimed to explore the chemopreventive mechanisms of lunasin through inflammatory mediators and estrogen-related molecules in breast cancer cells.

  3. What types of cells were used in the study?

    Estrogen-dependent MCF-7 and estrogen-independent MDA-MB-231 breast cancer cells were used.

  4. What were the main results of the study?

    Lunasin inhibited the growth of breast cancer cells, regulated inflammatory, angiogenic, and estrogen-related molecules, and showed a promising chemopreventive effect.

  5. Did lunasin affect normal cells?

    No, lunasin did not affect the growth of normal MCF-10A cells.

The information in this article was summarized from this article: https://foodandnutritionresearch.net/index.php/fnr/article/view/8991

Supplements Catalog

The goal of food supplements, also called dietary or nutritional supplements, is to provide nutrients that may not be consumed in sufficient quantities through the diet.

Food supplements can be vitamins, minerals, amino acids, fatty acids and other substances.

Colvita: Capsulas Colágeno Liofilizado + Algas con Magnesio + Vitamina E
Vendor: Colway
Colvita: Freeze-Dried Collagen Capsules + Algae with Magnesium and Zinc + Vitamin E
Regular price
From QAR 155,00
Regular price
QAR 0,00
Sale price
From QAR 155,00
SynbioCol: Live symbiotic
Vendor: Colway
SynbioCol: Live symbiotic
Regular price
QAR 425,00
Regular price
Sale price
QAR 425,00
Lunacol: Lunasina + Lisozina + Beta-glucanos | 60 caps
Vendor: Colway
Lunacol: Lunasin + Lysozine + Beta-glucans
Regular price
QAR 200,00
Regular price
QAR 178,00
Sale price
QAR 200,00
Axanta: Astaxantina + Piperina + Complex vitaminas B | 60 caps
Vendor: Colway
Axanta: Astaxantina + Piperina + Complex vitaminas B
Regular price
QAR 104,00
Regular price
QAR 0,00
Sale price
QAR 104,00
FungiCol: El mejor suplemento antioxidante y antienvejecimiento
Vendor: Colway
FungiCol: The best mushroom supplement with antioxidant and anti-aging effect
Regular price
QAR 178,00
Regular price
Sale price
QAR 178,00
Bebida de Colágeno para tu Piel, Pelo y Uñas - Oroborn
Vendor: Oroborn
Collagen Drink for your Skin, Hair, Joints and Nails - Oroborn
Regular price
QAR 217,00
Regular price
QAR 258,00
Sale price
QAR 217,00
BEAUTY&GO SKIN SHOT Suplemento bebible de colágeno
Vendor: Beauty&Go
BEAUTY&GO SKIN SHOT Drinkable collagen supplement
Regular price
QAR 145,00
Regular price
Sale price
QAR 145,00
Colgenium:  Prolina (PRP) aislado del calostro + VIT B6
Vendor: Colway
Colgenium: Proline (PRP) isolated from colostrum + VIT B6
Regular price
QAR 142,00
Regular price
Sale price
QAR 142,00
Babycol: Xilitol + Vit C, D, K + Colágeno para Niños - Masticable y Agradable Sabor
Vendor: Colway
Babycol: Xylitol + Vit C, D, K + Collagen for Kids - Chewable and Pleasant Taste
Regular price
QAR 73,00
Regular price
QAR 0,00
Sale price
QAR 73,00
DetoCol: Xyilitol + Vit C, D, K + Colágeno | 90 Caps
Vendor: Colway
DetoCol | Supporting a detox and anti-parasitic diet
Regular price
QAR 90,00
Regular price
Sale price
QAR 90,00
VITAMINA C-OLWAY | Pura Vitamina C
Vendor: Colway
Natural Vitamin C Pills for Collagen Production and Boosting Immunity
Regular price
QAR 85,00
Regular price
Sale price
QAR 85,00
Yguá Moringa Biodinámica
Vendor: Yguá
Yguá Biodynamic Moringa
Regular price
From QAR 26,00
Regular price
Sale price
From QAR 26,00
Vitamina C de Rosa Mosqueta con Colágeno Bio-Activo
Vendor: Colway
Rosehip Vitamin C with Bio-Active Collagen
Regular price
QAR 161,00
Regular price
Sale price
QAR 161,00

The latest from our blog

Visit our blog to always be up to date with the latest in the world of supplements!
Close
Edit Option
Close
Notify Me
is added to your shopping cart.
Close
Compare
Product SKU Description Collection Availability Product Type Other Details
Close
Close
Login
My Cart (0)

Before you leave

Take advantage of our First Purchase discount!

10% discount

Enter the code below at checkout to get your First Order discount

SAVE10

Continue buying
Recommendation 6