Skip to content

Ferroptosis in Osteoarthritis: The Role of Astaxanthin in Chondrocyte Health and Mitochondrial Function

Ferroptosis en la osteoartritis: el papel de la astaxantina en la salud de los condrocitos y la función mitocondrial

Osteoarthritis (OA) is a degenerative joint disease affecting millions worldwide, characterized by the progressive deterioration of cartilage. Recent research has shed light on the role of ferroptosis, a novel form of regulated cell death, in the advancement of OA. This article delves into the intricate relationship between ferroptosis and chondrocyte health in OA, highlighting the potential therapeutic role of Astaxanthin (ATX) in mitigating these effects.

Understanding Ferroptosis and Its Impact on Osteoarthritis

Ferroptosis is a type of cell death distinct from apoptosis and necrosis, primarily characterized by iron overload and the accumulation of reactive oxygen species (ROS) and lipid ROS. In the context of OA, ferroptosis in chondrocytes, the cells responsible for maintaining healthy cartilage, can accelerate the disease's progression.

The Role of IL-1β in Chondrocyte Ferroptosis

Interleukin-1β (IL-1β) is a cytokine known to induce inflammatory injury in chondrocytes. It promotes the expression of inflammatory factors such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX2). IL-1β triggers ferroptosis in chondrocytes by increasing intracellular ROS, lipid ROS, and iron levels while inhibiting the expression of critical proteins like SLC7A11/glutathione peroxidase 4 (GPX4) and Ferritin.

Mitochondrial Dysfunction in Chondrocyte Ferroptosis

Mitochondrial dysfunction is a hallmark of ferroptosis. In OA, IL-1β-induced ferroptosis leads to decreased mitochondrial membrane potential, membrane rupture, and changes in mitochondrial shape and cristae structure. These mitochondrial alterations are consistent with ferroptosis and contribute significantly to chondrocyte damage in OA.

Astaxanthin: A Potential Therapeutic Agent in Osteoarthritis

Astaxanthin (ATX), a xanthophyll carotenoid, is known for its anti-inflammatory and antioxidant properties. While its role in diabetes and cardiovascular disease has been explored, its potential in treating OA, particularly in the context of chondrocyte ferroptosis, is a novel area of research.

Astaxanthin's Mechanism of Action in Chondrocyte Health

ATX has been shown to counteract the effects of IL-1β in chondrocytes. It ameliorates the indices of ferroptosis by reducing ROS levels and restoring mitochondrial function. ATX also reverses the IL-1β-induced downregulation of collagen type II and upregulation of matrix metalloproteinase 13 (MMP13), crucial factors in maintaining cartilage integrity.

Astaxanthin and Ferrostatin-1 in Mitigating Osteoarthritis Progression

Both ATX and Ferrostatin-1 (Fer-1), a classic ferroptosis inhibitor, have shown promising results in delaying articular cartilage degradation and OA progression. Their combined use can significantly mitigate chondrocyte injury and osteoarthritis progression by inhibiting ferroptosis and regulating mitochondrial function.

Future Perspectives: Targeting Ferroptosis in Osteoarthritis Treatment

The study of ferroptosis in OA opens new avenues for treatment strategies. Targeting ferroptosis and its related pathways could be a promising approach to managing OA. The potential of ATX, in conjunction with other ferroptosis inhibitors like Fer-1, offers a novel therapeutic pathway that warrants further exploration.

Conclusion: A New Horizon in Osteoarthritis Therapy

The intricate relationship between ferroptosis, mitochondrial dysfunction, and chondrocyte health in OA presents a new frontier in understanding and treating this debilitating disease. The role of ATX, with its anti-inflammatory and antioxidant properties, in mitigating these effects, offers a beacon of hope for those suffering from OA. Continued research in this field is essential to fully realize the potential of targeting ferroptosis in OA treatment.

Supplements Catalog

The goal of food supplements, also called dietary or nutritional supplements, is to provide nutrients that may not be consumed in sufficient quantities through the diet.

Food supplements can be vitamins, minerals, amino acids, fatty acids and other substances.

Colvita: Capsulas Colágeno Liofilizado + Algas con Magnesio + Vitamina E
Vendor: Colway
Colvita: Freeze-Dried Collagen Capsules + Algae with Magnesium and Zinc + Vitamin E
Regular price
From Dhs. 404.00
Regular price
Sale price
From Dhs. 404.00
SynbioCol: Live symbiotic
Vendor: Colway
SynbioCol: Live symbiotic
Regular price
Dhs. 425.00
Regular price
Sale price
Dhs. 425.00
Lunacol: Lunasina + Lisozina + Beta-glucanos | 60 caps
Vendor: Colway
Lunacol: Lunasin + Lysozine + Beta-glucans
Regular price
Dhs. 416.00
Regular price
Dhs. 369.00
Sale price
Dhs. 416.00
Axanta: Astaxantina + Piperina + Complex vitaminas B | 60 caps
Vendor: Colway
Axanta: Astaxantina + Piperina + Complex vitaminas B
Regular price
Dhs. 404.00
Regular price
Sale price
Dhs. 404.00
FungiCol: El mejor suplemento antioxidante y antienvejecimiento
Vendor: Colway
FungiCol: The best mushroom supplement with antioxidant and anti-aging effect
Regular price
Dhs. 370.00
Regular price
Sale price
Dhs. 370.00
Colgenium:  Prolina (PRP) aislado del calostro + VIT B6
Vendor: Colway
Colgenium: Proline (PRP) isolated from colostrum + VIT B6
Regular price
Dhs. 295.00
Regular price
Sale price
Dhs. 295.00
Babycol: Xilitol + Vit C, D, K + Colágeno para Niños - Masticable y Agradable Sabor
Vendor: Colway
Babycol: Xylitol + Vit C, D, K + Collagen for Kids - Chewable and Pleasant Taste
Regular price
Dhs. 151.00
Regular price
Dhs. 0.00
Sale price
Dhs. 151.00
DetoCol: Xyilitol + Vit C, D, K + Colágeno | 90 Caps
Vendor: Colway
DetoCol | Supporting a detox and anti-parasitic diet
Regular price
Dhs. 186.00
Regular price
Sale price
Dhs. 186.00
VITAMINA C-OLWAY | Pura Vitamina C
Vendor: Colway
Natural Vitamin C Pills for Collagen Production and Boosting Immunity
Regular price
Dhs. 176.00
Regular price
Sale price
Dhs. 176.00
Yguá Moringa Biodinámica
Vendor: Yguá
Yguá Biodynamic Moringa
Regular price
From Dhs. 54.00
Regular price
Sale price
From Dhs. 54.00
Vitamina C de Rosa Mosqueta con Colágeno Bio-Activo
Vendor: Colway
Rosehip Vitamin C with Bio-Active Collagen
Regular price
Dhs. 335.00
Regular price
Sale price
Dhs. 335.00

The latest from our blog

Visit our blog to always be up to date with the latest in the world of supplements!
Close
Edit Option
Close
Notify Me
is added to your shopping cart.
Close
Compare
Product SKU Description Collection Availability Product Type Other Details
Close
Close
Login
My Cart (0)